Dana-Farber Cancer Institute (DFCI) and Deerfield Management have created the Center for Protein Degradation (CPD) at DFCI. The CPD has created a next-generation protein degrader and molecular glue platform to advance novel therapeutic modalities. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions.  Join our highly interactive team of scientists where we are creating new avenues of therapeutic intervention.

Our Culture

CPD believes...

• learning is paramount, failure is necessary to succeed, and humility is an asset.
• every individual should have the opportunity to provide and solicit feedback; asking for help is a strength.
• in helping others succeed – we celebrate our successes together and recognize the contributions of the team.
• in scientific excellence, challenging dogma, and asking “WHY?”
• our research must push scientific boundaries and accelerate the discovery of transformational medicines.

The Center for Protein Degradation (CPD) is seeking a biologist/biochemist to join the Biochemistry and Structural Biology team. The individual will work as part of a multidisciplinary team to identify and characterize novel molecular glues and degraders.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Conduct standardized biological or biochemical assays and laboratory analyses
• Maintain and perform drug treatments on cell cultures
• Prepare and maintain laboratory reagents and stocks
• Compile and analyze experimental data. Develop a summary of findings for presentation to Center personnel.
• Use computers, computer-interfaced equipment, robotics and/or high-technology applications to perform work duties
• Maintain work areas and order supplies, as needed
• Set up, calibrate and operate lab equipment
• Keep up to date with appropriate literature and research publications related to work and projects
• May be responsible for designing and executing advanced experiments
• Maintain clear and accurate records of experimental work (e.g., experiment methods, results/findings) in a lab notebook
• Monitor laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory. 

Specialized Responsibilities, by Scientific Area:

Biochemistry: Conduct standard biological or biochemical assays and laboratory analyses, e.g., TR-FRET, FP, AlphaScreen, ELISA, and cell-based assays, etc. Purify and prepare proteins for the in-vitro assays.

• Bachelor's Degree (required), with a major in biochemistry, chemical biology or biology is preferred
• At least 1 year lab experience post-Bachelor’s
• Knowledge of state-of-the-art information and techniques related to either biochemistry or chemical biology is preferred
• Must have excellent communication skills (written and verbal) and be able to keep accurate experimental records
• Ability to analyze information and use logic to address work-related issues and problems
• Must have close attention to detail and good time management
• Ability to work within a team environment

Typically has 1-3 years of previous professional experience.  Develops technical expertise and applies policies and procedures to resolve a variety of issues.  Works on problems of moderate scope where analysis of situations or data may require review of a variety of factors.  Exercises judgment within defined parameters to determine appropriate action.  Builds productive internal and external working relationships.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

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